Selection bias and information bias in clinical research.

نویسندگان

  • Giovanni Tripepi
  • Kitty J Jager
  • Friedo W Dekker
  • Carmine Zoccali
چکیده

The internal validity of an epidemiological study can be affected by random error and systematic error. Random error reflects a problem of precision in assessing a given exposure-disease relationship and can be reduced by increasing the sample size. On the other hand, systematic error or bias reflects a problem of validity of the study and arises because of any error resulting from methods used by the investigator when recruiting individuals for the study, from factors affecting the study participation (selection bias) or from systematic distortions when collecting information about exposures and outcomes (information bias). Another important factor which may affect the internal validity of a clinical study is confounding. In this article, we focus on two categories of bias: selection bias and information bias. Confounding will be described in a future article of this series.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Interpreting Ambiguous Social Situations in Social Anxiety: Application of Computerized Task Measuring Interpretation Bias

Background and Aims: The interpretation bias which is an important factor in the pathology of social anxiety disorder, has been recently considered in therapeutic approaches. Given the importance of interpretation bias in the treatment of social anxiety, and despite the ambiguity in the relationship between social anxiety and interpretation bias, we compared the interpretation bias in individua...

متن کامل

تصادفی سازی در مطالعات کارآزمایی بالینی: از تئوری تا عمل

Background & Aim: Randomized clinical trials (RCTs) are studies which are able to provide the most valid evidence to compare various interventions in health research. Biases can affect the quality of research and ultimately make the results of a study invalid. One of the most important biases is selection bias. The best way to reduce selection bias is the use of random allocation. The aim of th...

متن کامل

Prediction of Suicide Ideation Based on the Attentional Bias in Clinical and Non-clinical Populations

Objectives: This study aimed to predict the suicide ideation based on the attentional bias in clinical and non-clinical populations. Methods: Participants were 120 individuals (77 women and 43 men, age range 18-40 years) who were purposively selected and divided into three groups of clinical-suicidal (n=40), clinical non-suicidal (n=40) and non-clinical (n=40). They were measured by Suicide St...

متن کامل

Codon bias patterns in photosynthetic genes of halophytic grass Aeluropus littoralis

Codon bias refers to the differences in the frequency of occurrence of synonymous codons in coding DNA. Pattern of codon and optimum codon utilization is significantly different between the lives. This difference is due to the long term function of natural selection and evolution process. Genetics drift, mutation and regulation of gene expression are the main reasons for codon bias. In this stu...

متن کامل

Online Attentional Bias Modification Training for Adolescents with Internet Gaming Disorder

Objective: Previous research has shown that attentional bias towards game-related stimuli is a significant factor in the etiology, maintenance and severity of Internet Gaming Disorder (IGD). Therefore, interventions targeting attentional bias towards game-related stimuli, can potentially ameliorate this disorder. The aim of the present research was to examine the effectiveness of online Attenti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Nephron. Clinical practice

دوره 115 2  شماره 

صفحات  -

تاریخ انتشار 2010